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09-10.-2003, 02:23 PM
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#31 |
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Registered User
Join Date: Jun 2003
Location: Melbourne
Posts: 1,666
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Please can we let this go?
In PA: damage to parietal cells => loss of IF => low B12 => impaired DNA formation in the RBC precursors in the bone marrow => megaloblastic anaemia. PA is a cause of anaemia. Patients with PA are not necessarily anaemic. Following treatment with B12 injections, their haemoglobin will improve - ie they are no longer anaemic - but they are still labelled as having "PA" as still have those auto-antibodies and still have low IF. A vegan who gets low B12 due to poor intake and gets anaemic does not have PA. |
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09-10.-2003, 10:39 PM
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#32 |
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Guest
Posts: n/a
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Not when you're so wrong.
As I said, the anemia doesn't cause loss of IF. It's the antibodies. |
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10-10.-2003, 06:56 AM
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#33 |
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Registered User
Join Date: Jun 2003
Location: Melbourne
Posts: 1,666
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As Dr Evil said, "You just don't get it, do ya?"
Just say today, you were to develop what will become PA. For whatever reason, you start producing auto-antibodies today. Soon you will stop having enough IF. In a year or two your B12 store run out. After that you get anaemic. BUT, if someone were to test you next week and find you had positive anti-IF-Abs, you could be diagnosed with "Pernicious Anaemia" even though you are not anaemic and wouldn't be for probably a couple of years. Pernicious anaemia is a name of a disease that doesn't necessarily mean you are anaemic at the time. Again - please let it go. Just accept that you were wrong and move on! |
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